Laboratório de Inflamação Pulmonar
Publications
Scientific contributions to the study of lung inflammation and immunity
Harnessing the Farm Effect: Microbial Products for the Treatment and Prevention of Asthma Throughout Life
Esse artigo se trata de uma revisão da literatura sobre os efeitos protetores do meio rural na asma e alergias. Descreve importantes achados da literatura de como o meio ambiente rural pode modular a microbiota e consequentemente o sistema imunológico.
A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome
This was one of the most important articles from our group. At a time when probiotics are widely available on supermarket shelves and consumed indiscriminately, we demonstrated, using an experimental model, that uncontrolled probiotic use in allergic asthma can have distinct effects: beneficial for some individuals, but potentially harmful for others.
Prophylactic Supplementation of Bifidobacterium longum 51A Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness
This article demonstrates that an acetate-producing probiotic can prevent asthma exacerbation during menopause. In addition, we present a novel experimental model for studying asthma exacerbation in this context.
Exogenous acetate mitigates later enhanced allergic airway inflammation in a menopausal mouse model
In this article, we demonstrated that the administration of exogenous acetate can reduce asthma exacerbation during menopause in an experimental model. Acetate, a short-chain fatty acid produced by the gut microbiota, is able to reach the lungs. In our study, we observed that preventive treatment with acetate exerted a beneficial effect on lung health.
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
Esse artigo descreve a crotonilação de histonas no intestino, uma mudança epigenética, modulada pela produção de ácidos graxos de cadeia curta produzidos pela microbiota intestinal. Esse estudo mostra uma "conversa" entre a microbiota intestinal e o epitélio do intestino.
Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation
Overall, our results suggest that in humans, a temporary decrease in certain types of immune cells (lymphocytes), as well as individual characteristics such as genetic variations in a gene called Fas, can significantly influence how the body responds to inflammation in the lungs.
